Hi everyone, For our next journal club on Tuesday, May 13, we will explore a paper that merges two exciting and rapidly evolving fields: mRNA therapeutics and CNS-targeted drug delivery. "Blood–brain-barrier-crossing lipid nanoparticles for mRNA delivery to the central nervous system" published in Nature Materials, February 2025. 🔗 https://doi.org/10.1038/s41563-024-02114-5 The paper describes how lipid nanoparticles formulated with ionizable lipids inspired by brain-targeting small molecules enable efficient mRNA delivery across the blood–brain-barrier, a long-standing challenge in neurotherapeutics. I’m looking forward to hearing your thoughts and discussing the potential implications of this research for infectious diseases of the CNS. Best regards, Eva. Eva Anna Marianne Baerends, MSc PhD student Department of Infectious Diseases Aarhus University Hospital Palle Juul-Jensens Boulevard 99 8200 Aarhus N Denmark (+45) 27 11 87 32