Hi everyone,
For our next journal club on Tuesday, May 13, we will explore a paper that merges two exciting and rapidly evolving fields: mRNA therapeutics and CNS-targeted drug delivery.
"Blood–brain-barrier-crossing lipid nanoparticles for mRNA delivery to the central nervous system" published in Nature Materials, February 2025.
đź”— https://doi.org/10.1038/s41563-024-02114-5
The paper describes how lipid nanoparticles formulated with ionizable lipids inspired by brain-targeting small molecules enable efficient mRNA delivery across the blood–brain-barrier, a long-standing challenge in neurotherapeutics.
I’m looking forward to hearing your thoughts and discussing the potential implications of this research for infectious diseases of the CNS.
Best regards,
Eva.