Fra: Rune Hartmann <rh@mbg.au.dk>
Dato: mandag, 8. september 2025 kl. 14.02
Til: Alexander Zelikin <zelikin@chem.au.dk>, Christian Kanstrup Holm <holm@biomed.au.dk>, David Olagnier <olagnier@biomed.au.dk>, Edzard Spillner <e.spillner@bce.au.dk>, Henning Grønbæk <henning.gronbaek@aarhus.rm.dk>, Karen l Thomsen <karethom@rm.dk>, Ken Howard <kenh@inano.au.dk>, Line Reinert <line.reinert@biomed.au.dk>, Martin Kristian Thomsen <mkt@biomed.au.dk>, Martin Roelsgaard Jakobsen <mrj@biomed.au.dk>, Martin Tolstrup <mtol@clin.au.dk>, Ryo Narita <rnarita@biomed.au.dk>, Sofie Eg Jørgensen <segj@biomed.au.dk>, Søren Egedal Degn <sdegn@biomed.au.dk>, Søren Riis Paludan <srp@biomed.au.dk>, Trine Hyrup Mogensen <trinmoge@rm.dk>
Emne: Guest lecture on EVs and virus infection – Mon (kl.15-16) next week

Please see below

Rune Hartmann

PhD, Professor of innate immunology

Novo Nordisk Foundation - Distinguished Investigator

Section for RNA biology and Innovation

Dept. of Molecular Biology and Genetics; Aarhus University.

Universitetsbyen 81, 8000 Aarhus C

++45 2899 2578

https://mbg.au.dk/en/rune-hartmann

From: Yuya Hayashi <yuya.hayashi@mbg.au.dk>
Sent: 8. september 2025 13:46
To: #MBG NY <ny.mbg@list.au.dk>
Subject: Guest lecture on EVs and virus infection – Mon (kl.15-16) next week

Dear All,

In connection with the PhD course Infection and Immunity seminar series, Associate Professor Esther Nolte-'t Hoen from Utrecht University (also the current president of the Netherlands Society for Extracellular Vesicles) will visit us next Mon & Tue to give lectures on her recent work on EVs and virus infection. If interested, you're welcome to attend the lecture on Mon (15th) 😉

Date and Time: 15th (Mon), kl. 15-16

Place: Faculty Club (1870-816)

Extracellular vesicles in the context of immune defense

Esther Nolte-‘t Hoen, Utrecht University, The Netherlands

There is an enormous rise in interest in extracellular vesicles (EVs) as means of intercellular communication. The 50-300 nm sized EVs contain lipids, (membrane-bound) proteins, and nucleic acids. Release and uptake of EVs is a highly conserved means of communication used by cells in many organisms across all kingdoms of life. EVs have been implicated in several diseases, including immune-related disorders, cancer, infection, and cardiovascular diseases.

Our current work focuses on non-enveloped (naked) viruses, mainly those belonging to the family Picornaviridae. These naked viruses can escape intact cells via enclosure in EVs. Inside these EVs, virions can stay under the radar of the host’s immune system. We previously described an important role for the viral non-structural proteins and modulation of specific host kinases in the induction of these EV-enclosed viruses. In contrast to naked viruses, the EV-enclosed viruses can efficiently transmit infection in the presence of neutralizing antibodies. Although these EVs undermine antiviral defense via the humoral immune response, our recent work shows that monocytes recognize and respond to virus-induced EVs by production of antiviral cytokines.

Combined. these findings shed light on the diverse effects of picornavirus-induced EVs on virus spreading and the antiviral immune response.

Regards,

Yuya