October 2025 - Hauser.chem

Organic Synthesis&Biocatalysis GM
by Nicole Maria Hauser 21 Oct '25

21 Oct '25

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Organic Synthesis&Biocatalysis GM
by Nicole Maria Hauser 21 Oct '25

21 Oct '25

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Organic Synthesis&Biocatalysis GM
by Nicole Maria Hauser 21 Oct '25

21 Oct '25

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Organic Synthesis&Biocatalysis GM
by Nicole Maria Hauser 21 Oct '25

21 Oct '25

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Organic Synthesis and Biocatalysis
by Nicole Maria Hauser 21 Oct '25

21 Oct '25

Dear Group, I am trying to schedule individual meetings now because of changing locations. Best, Nicole

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[org.chem] Lecture by Matthias Gehringer Thursday 23-10-2025
by Vibeke Henriette Lauridsen 20 Oct '25

20 Oct '25

Speaker: Prof. Matthias Gehringer, University of Tübingen, Germany Time-Place: Thursday 23/10-2025 10.15 in 1511-312 (krydsfeltet) Title: Covalent Protein Kinase Inhibitors: Exploring Understudied Targets and Unconventional Binding Modes Abstract: Protein kinases have been pursued as drug targets for more than 20 years, but a significant part of the human "kinome" has not yet been addressed with specific inhibitors, despite its likely medical relevance. Our research group focuses on the identification of new covalent inhibitors for both validated and understudied protein kinases. Through our recent work, we and our collaborators have employed rational design approaches as well as intact-protein mass spectrometry (MS) screens to explore kinase-inhibitor-like covalent libraries equipped with cysteine and tyrosine/lysine reactive "warheads". These efforts have yielded a variety of promising hits. In addition to mass spectrometry, we utilized a suite of complementary methods, including thermal shift assays, biochemical enzyme assays, cellular assays, and X-ray crystallography, for further investigation and thorough validation. My presentation will detail our progress in extending the range of known protein kinase inhibitors, especially focusing on new inhibitors of lesser-studied kinases. Additionally, I will discuss non-conventional binding modes we have identified, which provide a basis for ongoing medicinal chemistry optimization. These results help to unlock a broader range of kinase targets and support current and future efforts in kinase inhibitor development. _______________________________________________ org.chem mailing list -- org.chem(a)maillist.au.dk

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Balance
by Nicole Maria Hauser 17 Oct '25

17 Oct '25

Dear group, Please keep the balance clean, picture attached. This makes me not want to touch anything in lab without gloves. I also closed the open waste containers. Please remember to do that when you leave, in particular but not only over the weekend. Best Nicole Get Outlook for Android<https://aka.ms/AAb9ysg>

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Fw:
by Fabien Fritz 17 Oct '25

17 Oct '25

________________________________ Von: Fabien Fritz Gesendet: Friday, October 17, 2025 2:52:09 PM An: gr109.chem(a)maillist.au.dk <gr109.chem(a)maillist.au.dk> Betreff:

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Fw: PO 102822
by Nicole Maria Hauser 16 Oct '25

16 Oct '25

FYI. I will keep you updated as soon as I know more about the installation/training. ________________________________ From: marekd(a)md-scientific.dk <marekd(a)md-scientific.dk> Sent: Friday, October 10, 2025 1:46 PM To: Nicole Maria Hauser <nhauser(a)chem.au.dk> Subject: SV: PO 102822 And here are the forgotten attachments ☹. *********************************** Med venlig hilsen / Best regards Marek Danielewicz, PhD MD Scientific ApS Klokkerfaldet 23 8210 Aarhus V, Denmark Phone: +45 7027 8565 Cell: +45 2483 9967 E-mail: marekd(a)md-scientific.dk<mailto:marekd@md-scientific.dk> www.md-scientific.dk<http://www.md-scientific.dk/> Fra: marekd(a)md-scientific.dk <marekd(a)md-scientific.dk> Sendt: 10. oktober 2025 13:38 Til: 'Nicole Maria Hauser' <nhauser(a)chem.au.dk> Emne: SV: PO 102822 Hi Nicole Unfortunately, Moritz have not finalized his planning for the following weeks. Week 43 sounds good, but he will have to confirm later. Would week 44 be ok as well ? Further he asked me to send you the following information for the installation and training. For installation and training, we would need the following requirements: - Space: 40 cm wide x 51 cm deep x 75 cm high. The system can be set up outside a fume hood. The exhaust gases from the collector need to be diverted to the air venting system. - Power: 1 x 220 V outlet - Solvent: Doesn't have to be HPLC-grade, but mostly particle-free: cyclohexane or similar, ethyl acetate, and any other solvents for your runs/samples. - In case we want to work in reversed phase: water and ACN/MeOH. I have a C18 test column with me that we can try out. - Consumables: Tissue paper, 2 ml and/or 5 ml syringes, needles - Waste: A waste container (e.g., a 2.5 L bottle or canister) - Test tubes: 9 mm, preferably a whole carton - For the iELSD, we need a small amount of HPLC-grade isopropanol or ethanol (250 ml or 500 ml is sufficient for now) - iELSD gas: The gas tubing has a 6 mm OD. We would need a corresponding adapter at the gas outlet, which should also have a pressure gauge. The line requirements are very low: 1.2 bar and 1 L/min are sufficient. For the training: - We want to make the training as realistic as possible. It would therefore be ideal if you could prepare some real samples. Attached you will find the loading table, which I will explain again during the training. Between 50 mg and 1 g of sample can be loaded onto an F0012 cartridge, with the load depending largely on the difficulty of the separation problem (see DeltaCV). The software helps with the selection. For training, sample quantities of 100 mg to 400 mg would be perfect. - A suitable TLC for the respective sample is also welcome, with values ideally between Rf 0.1 and Rf 0.35 (or at least one of these values). - You are welcome to download the free app "TLC to Flash and Prep" in advance. With the app, we can simply take a photo of the TLC and send it to the device via Bluetooth. For normal-phase separations, many samples are not well soluble under the initial conditions of the run (high proportion of the less polar solvent). In this case, a dry load is recommended. I will bring a few test cartridges so that we can run through the process during the training. For the DryLoad, we need: - Sample bonded onto silica/Celite/Isolute in a ratio of 1 part sample to 2 parts Celite/silica - Some material to fill the DryLoad cartridge. An old wash bottle filled with sea sand is ideal. If you cut off the top of the syringe, you can simply pump the sea sand into the DryLoad to fill it up. - A small tripod with a clamp for filling the DryLoad is helpful We look forward to the training and installation. Best regards Marek *********************************** Med venlig hilsen / Best regards Marek Danielewicz, PhD MD Scientific ApS Klokkerfaldet 23 8210 Aarhus V, Denmark Phone: +45 7027 8565 Cell: +45 2483 9967 E-mail: marekd(a)md-scientific.dk<mailto:marekd@md-scientific.dk> www.md-scientific.dk<http://www.md-scientific.dk/> Fra: Nicole Maria Hauser <nhauser(a)chem.au.dk<mailto:nhauser@chem.au.dk>> Sendt: 10. oktober 2025 10:15 Til: marekd(a)md-scientific.dk<mailto:marekd@md-scientific.dk> Emne: RE: PO 102822 Hi Marek, Yes, I received a tracking notification from the company yesterday. We are looking forward! Installation in week 43 works. Do you know exactly when? Thank you and best, Nicole From: marekd(a)md-scientific.dk<mailto:marekd@md-scientific.dk> <marekd(a)md-scientific.dk<mailto:marekd@md-scientific.dk>> Sent: Thursday, October 9, 2025 10:09 PM To: Nicole Maria Hauser <nhauser(a)chem.au.dk<mailto:nhauser@chem.au.dk>> Subject: SV: PO 102822 Hi Nicole Good news — your PF 5.050 will be shipped this week! Delivery to Aarhus should take about 4–5 days, so we expect it to arrive by the end of next week. Moritz has suggested scheduling the installation for the following week (week 43). Would that work for you? Best regards Marek *********************************** Med venlig hilsen / Best regards Marek Danielewicz, PhD MD Scientific ApS Klokkerfaldet 23 8210 Aarhus V, Denmark Phone: +45 7027 8565 Cell: +45 2483 9967 E-mail: marekd(a)md-scientific.dk<mailto:marekd@md-scientific.dk> www.md-scientific.dk<http://www.md-scientific.dk/> Fra: marekd(a)md-scientific.dk<mailto:marekd@md-scientific.dk> <marekd(a)md-scientific.dk<mailto:marekd@md-scientific.dk>> Sendt: 18. september 2025 09:03 Til: 'Nicole Maria Hauser' <nhauser(a)chem.au.dk<mailto:nhauser@chem.au.dk>> Emne: SV: PO 102822 Hi Nicole No problem and I hope everything is fine with you family. I sent your answer to Moritz so if they need more information I will contact you. Best regards Marek Fra: Nicole Maria Hauser <nhauser(a)chem.au.dk<mailto:nhauser@chem.au.dk>> Sendt: 18. september 2025 08:39 Til: marekd(a)md-scientific.dk<mailto:marekd@md-scientific.dk> Emne: RE: PO 102822 Hi Marek, Apologies for the delay. I also just saw that I missed your phone call yesterday. I was in Switzerland for a family emergency and just came back. Should it be 3 racks of the same size, I guess? We would then like the 9 mL ones, these: [cid:image001.png@01DC39EB.D2472D10] Is there anything else we should discuss? I am also happy to talk on the phone later today, e.g. at 10:30 today. Thank you and best, Nicole From: marekd(a)md-scientific.dk<mailto:marekd@md-scientific.dk> <marekd(a)md-scientific.dk<mailto:marekd@md-scientific.dk>> Sent: Monday, September 15, 2025 1:49 PM To: Nicole Maria Hauser <nhauser(a)chem.au.dk<mailto:nhauser@chem.au.dk>> Subject: VS: PO 102822 Hi Nicole Could you please specify which rack size you would like to be delivered with the system (see attached)? You will be getting 3 racks with the PF 5.050 instrument. Are you also using the small tubes? Best regards Marek *********************************** Med venlig hilsen / Best regards Marek Danielewicz, PhD MD Scientific ApS Klokkerfaldet 23 8210 Aarhus V, Denmark Phone: +45 7027 8565 Cell: +45 2483 9967 E-mail: marekd(a)md-scientific.dk<mailto:marekd@md-scientific.dk> www.md-scientific.dk<http://www.md-scientific.dk/>

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Organic Synthesis & Biocatalysis GM
by Nicole Maria Hauser 15 Oct '25

15 Oct '25

Dear all, This is the invite for our group meetings every Thursday from 8:15. We start this week with a presentation I will give as a practice talk. Best, Nicole

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